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Suzuki–Miyaura Coupling of Aryl Chlorides with Arylboronic Acids Using the Morpholine–NiCl 2 Catalyst System
Author(s) -
Abe Taichi,
Mino Takashi,
Watanabe Kohei,
Sakamoto Masami
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402881
Subject(s) - morpholine , chemistry , catalysis , aryl , reagent , organic chemistry , combinatorial chemistry , nickel , alkyl
We report a new catalyst system, morpholine–NiCl 2 , for the Suzuki–Miyaura coupling of aryl chlorides with aryl‐ or alkenylboronic acids to give biaryl compounds. This catalyst system is easy to apply on a large scale because of its easy preparation and the use of inexpensive reagents. In addition, analysis of the residual nickel shows only 9.7 ppm remaining after normal work‐up. This catalyst system has been applied to 26 compounds to give a variety of biaryl products, including hetero‐biaryl compounds.