A Unified Strategy Towards  N ‐Aryl Heterocycles by a One‐Pot Copper‐Catalyzed Oxidative C–H Amination of Azoles | Zendy

Subramanian Parthasarathi | Zendy; Kaliappan Krishna P. | Zendy

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A Unified Strategy Towards N ‐Aryl Heterocycles by a One‐Pot Copper‐Catalyzed Oxidative C–H Amination of Azoles

Author(s) -

Subramanian Parthasarathi,

Kaliappan Krishna P.

Publication year - 2014

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201402868

Subject(s) - chemistry , amination , intramolecular force , catalysis , aryl , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , copper , oxidative phosphorylation , organic chemistry , receptor , biochemistry , alkyl

An efficient one‐pot synthesis of N ‐aryl‐substituted heterocycles by a Cu‐catalyzed two‐fold C–N bond formation is reported. This strategy involves a Cu I ‐catalyzed C–N bond‐forming reaction between azoles and electron‐deficient bromopyridines followed by an intramolecular sp 2 C–H amination. One of the products thus formed has been successfully used as a ligand for the synthesis of a Pd complex.

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