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A Unified Strategy Towards N ‐Aryl Heterocycles by a One‐Pot Copper‐Catalyzed Oxidative C–H Amination of Azoles
Author(s) -
Subramanian Parthasarathi,
Kaliappan Krishna P.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402868
Subject(s) - chemistry , amination , intramolecular force , catalysis , aryl , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , copper , oxidative phosphorylation , organic chemistry , receptor , biochemistry , alkyl
An efficient one‐pot synthesis of N ‐aryl‐substituted heterocycles by a Cu‐catalyzed two‐fold C–N bond formation is reported. This strategy involves a Cu I ‐catalyzed C–N bond‐forming reaction between azoles and electron‐deficient bromopyridines followed by an intramolecular sp 2 C–H amination. One of the products thus formed has been successfully used as a ligand for the synthesis of a Pd complex.