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Copper‐Catalyzed Asymmetric Addition to Isatins to give 3‐Hydroxy‐2‐oxindoles by C–H Activation
Author(s) -
Deng Tao,
Wang Hongjun,
Cai Chun
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402852
Subject(s) - chemistry , oxazoline , catalysis , copper , ligand (biochemistry) , medicinal chemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry
A copper‐catalyzed asymmetric addition to isatins to give 3‐hydroxy‐2‐oxindoles by C–H activation with a fluorous bis(oxazoline) as ligand is presented. The corresponding products were obtained in 35–66 % yields with enantioselectivities up to 92 %. The fluorous ligand can be easily recovered and reused at least three times without significant loss in its activity.