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The Nazarov Cyclization: A Valuable Method to Synthesize Fully Substituted Carbon Stereocenters
Author(s) -
Wenz Donald R.,
Read de Alaniz Javier
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402825
Subject(s) - stereocenter , cyclopentane , chemistry , carbon fibers , combinatorial chemistry , task (project management) , enantioselective synthesis , stereochemistry , organic chemistry , catalysis , computer science , algorithm , management , composite number , economics
The synthesis of fully substituted carbon stereocenters remains a challenging task in organic chemistry. Recent developments in the design of substrates that undergo the Nazarov cyclization have enabled this reaction to become a valuable way to form elaborately substituted cyclopentane rings containing fully substituted carbon stereocenters. Three major strategies have been utilized in this endeavor. Here we provide an overview of these three areas that should give insight into the usage of the Nazarov reaction for the challenging task of forming fully substituted carbon stereocenters.