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Asymmetric Assembly of Steroidal Tetracyclic Skeletons
Author(s) -
Gupta Preeti,
Panda Gautam
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402822
Subject(s) - enantioselective synthesis , chemistry , combinatorial chemistry , organic synthesis , lewis acids and bases , reagent , structural motif , stereochemistry , molecule , organic chemistry , catalysis , biochemistry
Steroids have long played a vital role in organic synthesis because of their unique structural motif and associated biological properties. In recent years, asymmetric synthesis has emerged as a powerful tool for assembling the tetracyclic framework with high levels of molecular diversity. This review summarizes the latest developments in the enantioselective syntheses of both natural and synthetic steroids incorporating the carbocyclic skeleton. The approaches to the synthesis of steroids and related molecules are based primarily on the use of chiral starting materials, the employment of reagent‐controlled asymmetric induction assisted by chiral complexes, chiral Lewis acids or organocatalysts, or the utilisation of chiral auxiliaries.