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2‐Nitroglycals: Versatile Building Blocks for the Synthesis of 2‐Aminoglycosides
Author(s) -
Delaunay Thierry,
Poisson Thomas,
Jubault Philippe,
Pannecoucke Xavier
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402805
Subject(s) - chemistry , context (archaeology) , combinatorial chemistry , reactivity (psychology) , chemical biology , natural (archaeology) , biochemistry , biology , medicine , paleontology , alternative medicine , pathology
2‐Deoxy‐2‐amino‐substituted glycosides are ubiquitous compounds in biochemistry and biology. Therefore, the development of new synthetic pathways to access natural and non‐natural derivatives is highly desirable. In that context, 2‐nitroglycals appeared as versatile building blocks for reaching those targets. Since their first introduction almost forty years ago, their synthetic utility has been widely demonstrated and they have been used to access natural and non‐natural compounds with potent biological activity. The aim of this review is to summarize the developed routes to these versatile intermediates as well as their reactivity. The main applications of the chemistry developed with 2‐nitroglycal derivatives is also highlighted in this first review.