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β‐Lactam Bioconjugates Bearing Luminescent Platinum(II) Tags: Synthesis and Photophysical Characterization
Author(s) -
Soldati Roberto,
Aliprandi Alessandro,
Mauro Matteo,
De Cola Luisa,
Giacomini Daria
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402740
Subject(s) - chemistry , luminescence , platinum , excited state , pyridine , metal , combinatorial chemistry , ligand (biochemistry) , photochemistry , metal ions in aqueous solution , ion , catalysis , organic chemistry , biochemistry , physics , receptor , optoelectronics , nuclear physics
Two novel neutral complexes based on platinum metal ions, a tridentate ligand, and a pyridine bearing a β‐lactam unit have been synthesized and their photophysical properties investigated. The complexes show interesting emission properties that, in the solid state, are dominated by the formation of aggregates due to the square‐planar geometry of the Pt II species. Importantly, the formation of closed‐shell metal ··· metal interactions in such aggregates leads to new excited states that conveniently allow excitation in the visible region. The combination of the biologically active azetidinone agent and the intense and long‐lived emission are of particular interest for developing efficient multifunctional biomedical systems.