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Reagent‐Controlled Cyclization–Deprotection Reaction to Yield either Fluorenes or Benzochromenes
Author(s) -
Killander Dan,
Sterner Olov
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402722
Subject(s) - fluorene , chemistry , reagent , demethylation , alkylation , friedel–crafts reaction , yield (engineering) , intramolecular force , organic chemistry , combinatorial chemistry , catalysis , polymer , biochemistry , gene expression , materials science , metallurgy , dna methylation , gene
Compounds with benzochromene and fluorene structures are common in nature and society, and they can have potentially useful biological activities. In this paper, conditions for the selective preparation of either a benzochromene or a fluorene from the same starting material are described. The procedure uses a reagent‐controlled cyclization–demethylation to give the benzochromene, or an intramolecular Friedel–Crafts‐type alkylation to give the fluorene.