Syntheses of 4‐Substituted 2‐(Trichloromethyl)quinazolines under Mild Conditions by Benzyne [4+2] Cycloaddition | Zendy

LechugaEduardo Harim | Zendy; Olivo Horacio F. | Zendy; RomeroOrtega Moises | Zendy

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Syntheses of 4‐Substituted 2‐(Trichloromethyl)quinazolines under Mild Conditions by Benzyne [4+2] Cycloaddition

Author(s) -

LechugaEduardo Harim,

Olivo Horacio F.,

RomeroOrtega Moises

Publication year - 2014

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201402706

Subject(s) - aryne , chemistry , cycloaddition , reagent , aryl , acetal , medicinal chemistry , organic chemistry , combinatorial chemistry , catalysis , alkyl

An experimentally simple and convenient synthesis of 4‐susbstituted 2‐(trichloromethyl)quinazolines by cycloaddition of benzyne with 2‐(trichloromethyl)‐1,3‐diazabutadienes was developed. The 2‐(trichloromethyl)‐1,3‐diazabutadienes (R 1 = H and Me) were prepared from trichloroacetamidine and the appropriate N , N ‐dimethylamide dimethyl acetal or from trichloroacetamidine and a Vilsmeier–Haack reagent containing an aryl group.

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