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Synthesis of exo ‐Enamides from Protected Lactams Using a Modified Julia Olefination Reaction: Application to the Synthesis of Spiroaminal Fragments
Author(s) -
Gigant Nicolas,
Habib Samuel,
Medoc Marie,
Goekjian Peter G.,
Gueyrard David,
Gillaizeau Isabelle
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402681
Subject(s) - chemistry , combinatorial chemistry , transformation (genetics) , stereochemistry , biochemistry , gene
A modified Julia olefination (Julia–Kocienski) reaction involving lactams has been developed, which gives the corresponding substituted exo ‐enamides in moderate to good yields. An application of this versatile transformation in the synthesis of spiroaminal fragments is also demonstrated.