Premium
Synthesis and Structural Characterization of 2:1 [α/Aza]‐oligomers
Author(s) -
Zhou Zhou,
Deng Cheng,
Abbas Cécile,
Didierjean Claude,
AverlantPetit MarieChristine,
Bodiguel Jacques,
Vanderesse Régis,
JamartGrégoire Brigitte
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402628
Subject(s) - characterization (materials science) , chemistry , hydrogen bond , inducer , fourier transform infrared spectroscopy , diffraction , stereochemistry , molecule , oligomer , crystallography , materials science , polymer chemistry , nanotechnology , organic chemistry , chemical engineering , biochemistry , physics , engineering , gene , optics
Abstract The design of a new β‐turn inducer is correlated to the discovery of new foldamers. In this paper, we report the liquid phase synthesis of 2:1 [α/aza]‐oligomers using a convergent Boc strategy. The NMR, FTIR, restrained molecular dynamics and X‐ray diffraction analyses show that 2:1 [α/aza]‐oligomers adopt a C=O( i ) ··· H–N( i + 2) hydrogen‐bonded helical conformation.