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Efficient Synthesis of Isothiochromene Derivatives by Pd‐Catalyzed Hydrothiolation Reaction
Author(s) -
Feng Jie,
Lv Meifang,
Lu Guoping,
Cai Chun
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402611
Subject(s) - chemistry , thiourea , catalysis , palladium , intramolecular force , halide , combinatorial chemistry , cascade reaction , selectivity , sulfur , reaction conditions , organic chemistry
An efficient method for the preparation of isothiochromene derivatives through the palladium‐catalyzed intramolecular hydrothiolation reaction of halides and thiourea is reported. Two carbon–sulfur bonds are formed in this one‐pot palladium‐catalyzed cascade reaction. This new protocol is free from foul‐smelling thiols and operates under mild conditions to give isothiochromene derivatives in excellent yields and with excellent 6‐ endo ‐ dig selectivity.