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An Efficient Method for Enhancing the Reactivity and Flexibility of [ 18 F]Fluoride Towards Nucleophilic Substitution Using Tetraethylammonium Bicarbonate
Author(s) -
Brichard Laurent,
Aigbirhio Franklin I.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402587
Subject(s) - chemistry , fluoride , tetraethylammonium , bicarbonate , reactivity (psychology) , nucleophile , inorganic chemistry , evaporation , nucleophilic substitution , aqueous solution , hydrogen fluoride , elution , carbonate , organic chemistry , chromatography , catalysis , potassium , medicine , physics , alternative medicine , pathology , thermodynamics
The standard method used to generate reactive [ 18 F]fluoride for [ 18 F]radiolabelling is to trap it on an anion‐exchange cartridge then elute it with a basic aqueous solution, which is then subjected to azeotropic evaporation to remove water. We have now developed a method through the use of tetraethylammonium hydrogen carbonate in which we can obtain efficient recovery of [ 18 F]fluoride (up to 99 %), remove the requirement for the time‐consuming and inefficient azeotropic evaporation process and produce a reactive [ 18 F]fluoride that can undergo a wide range of aliphatic and aromatic [ 18 F]nucleophilic substitutions in up to 93 % radiochemical conversion at end‐of‐synthesis in the presence or without water.