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Indium‐Catalyzed Hydroamination/Hydrosilylation of Terminal Alkynes and Aromatic Amines through a One‐Pot, Two‐Step Protocol
Author(s) -
Sakai Norio,
Takahashi Nobuaki,
Ogiwara Yohei
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402544
Subject(s) - hydrosilylation , chemistry , hydroamination , markovnikov's rule , catalysis , organic chemistry , imine , tribromide , substrate (aquarium) , indium , combinatorial chemistry , polymer chemistry , regioselectivity , oceanography , geology
We demonstrated that indium tribromide effectively functioned as a single catalyst for two successive steps in a one‐pot procedure. First, the hydroamination of alkynes with anilines took place to give the Markovnikov product. Then, hydrosilylation of the imine intermediates by treatment with a hydrosilane substrate afforded the corresponding secondary amines.