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Oxidative Trifluoromethylthiolation of Terminal Alkynes with AgSCF 3 : A Convenient Approach to Alkynyl Trifluoromethyl Sulfides
Author(s) -
Zhu ShengQing,
Xu XiuHua,
Qing FengLing
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402533
Subject(s) - chemistry , trifluoromethyl , electrophile , dimethylacetamide , terminal (telecommunication) , combinatorial chemistry , electrophilic fluorination , medicinal chemistry , organic chemistry , catalysis , telecommunications , alkyl , solvent , computer science
A new method for the efficient synthesis of alkynyl trifluoromethyl sulfides was developed. By combining AgSCF 3 and NCS in N , N ‐dimethylacetamide, an electrophilic active intermediate was produced, which was then treated with a variety of terminal alkynes to afford the corresponding trifluoromethanesulfenylated products in moderate to excellent yields.