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Direct Fluoroalkylation of Indoles with Fluoroalkyl Halides Mediated by Copper
Author(s) -
He RuYi,
Zeng HuiTing,
Huang JingMei
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402526
Subject(s) - chemistry , halide , indole test , copper , combinatorial chemistry , organic chemistry
An efficient and mild copper‐mediated reaction for the direct perfluoroalkylation and difluoromethylation of indoles with perfluoroalkyl halides and ICF 2 COOEt to produce 2‐substituted indoles was developed. Both free indole derivatives and N‐substituted indole derivatives could be used in this process to obtain the desired products in moderate to good yields.