Hypervalent Iodine(III) Promoted Direct Synthesis of Imidazo[1,2‐ a ]pyrimidines | Zendy

Qian Guangyin | Zendy; Liu Bingxin | Zendy; Tan Qitao | Zendy; Zhang Siwen | Zendy; Xu Bin | Zendy

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Hypervalent Iodine(III) Promoted Direct Synthesis of Imidazo[1,2‐ a ]pyrimidines

Author(s) -

Qian Guangyin,

Liu Bingxin,

Tan Qitao,

Zhang Siwen,

Xu Bin

Publication year - 2014

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201402456

Subject(s) - hypervalent molecule , chemistry , bicyclic molecule , iodine , pyrimidine , intramolecular force , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry

An efficient and mild synthesis of imidazo[1,2‐ a ]pyrimidine derivatives has been developed from readily available pyrimidyl arylamines or enamines through a hypervalent iodine‐promoted intramolecular C–H bond cycloamination reaction. This protocol allows for the facile construction of biologically active bicyclic imidazo[1,2‐ a ]pyrimidine skeletons as well as other imidazo[1,2‐ a ]‐type fused heterocycles.

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