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Hypervalent Iodine(III) Promoted Direct Synthesis of Imidazo[1,2‐ a ]pyrimidines
Author(s) -
Qian Guangyin,
Liu Bingxin,
Tan Qitao,
Zhang Siwen,
Xu Bin
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402456
Subject(s) - hypervalent molecule , chemistry , bicyclic molecule , iodine , pyrimidine , intramolecular force , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry
An efficient and mild synthesis of imidazo[1,2‐ a ]pyrimidine derivatives has been developed from readily available pyrimidyl arylamines or enamines through a hypervalent iodine‐promoted intramolecular C–H bond cycloamination reaction. This protocol allows for the facile construction of biologically active bicyclic imidazo[1,2‐ a ]pyrimidine skeletons as well as other imidazo[1,2‐ a ]‐type fused heterocycles.