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Enantioselective Organocatalytic Conjugate Addition of Alkenes to α,β‐Enones
Author(s) -
Cui Lingyun,
Zhang Long,
Luo Sanzhong,
Cheng JinPei
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402353
Subject(s) - enantioselective synthesis , chemistry , conjugate , organocatalysis , organic chemistry , addition reaction , catalysis , adduct , combinatorial chemistry , mathematical analysis , mathematics
We report the first example of the enantioselective conjugate addition of alkenes (aromatic enamines) to enones catalyzed by chiral primary amines. The reactions encompass a plethora of α,β‐enones including difficult α‐substituted vinyl ketones to give vinylation adducts in high yields with good enantioselectivity. The methodology is of synthetic potential in accessing chiral functional materials.