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Copper(I)‐Catalyzed Decarboxylative Coupling of Propiolic Acids with Secondary Amines and Aldehydes
Author(s) -
Ermolat'ev Denis S.,
Feng Huangdi,
Song Gonghua,
Van der Eycken Erik V.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402338
Subject(s) - chemistry , aldehyde , amine gas treating , catalysis , copper , organic chemistry , decarboxylation , coupling reaction , combinatorial chemistry
Abstract An efficient microwave‐assisted synthesis of tertiary propargylamines has been developed by copper(I)‐catalyzed decarboxylative A 3 ‐coupling reaction of an alkynylcarboxylic acid with a secondary amine and an aldehyde. A wide range of diversely substituted propargylamines could be synthesized in high yields. The optimal reaction conditions are also effective for 3‐alkylpropiolic acids and for terminal propiolic acid.