Direct Amidation of Carboxylic Acids with Tertiary Amines: Amide Formation over Copper Catalysts through C–N Bond Cleavage | Zendy

Xiong Biquan | Zendy; Zhu Longzhi | Zendy; Feng Xiaofeng | Zendy; Lei Jian | Zendy; Chen Tieqiao | Zendy; Zhou Yongbo | Zendy; Han LiBiao | Zendy; Au ChakTong | Zendy; Yin ShuangFeng | Zendy

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Direct Amidation of Carboxylic Acids with Tertiary Amines: Amide Formation over Copper Catalysts through C–N Bond Cleavage

Author(s) -

Xiong Biquan,

Zhu Longzhi,

Feng Xiaofeng,

Lei Jian,

Chen Tieqiao,

Zhou Yongbo,

Han LiBiao,

Au ChakTong,

Yin ShuangFeng

Publication year - 2014

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201402332

Subject(s) - chemistry , cleavage (geology) , copper , bond cleavage , amide , catalysis , peptide bond , carboxylic acid , organic chemistry , combinatorial chemistry , medicinal chemistry , polymer chemistry , stereochemistry , geotechnical engineering , fracture (geology) , engineering , enzyme

A copper‐catalyzed system for the amidation of carboxylic acids with tert ‐amines through C–N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction.

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