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Direct Amidation of Carboxylic Acids with Tertiary Amines: Amide Formation over Copper Catalysts through C–N Bond Cleavage
Author(s) -
Xiong Biquan,
Zhu Longzhi,
Feng Xiaofeng,
Lei Jian,
Chen Tieqiao,
Zhou Yongbo,
Han LiBiao,
Au ChakTong,
Yin ShuangFeng
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402332
Subject(s) - chemistry , cleavage (geology) , copper , bond cleavage , amide , catalysis , peptide bond , carboxylic acid , organic chemistry , combinatorial chemistry , medicinal chemistry , polymer chemistry , stereochemistry , geotechnical engineering , fracture (geology) , engineering , enzyme
A copper‐catalyzed system for the amidation of carboxylic acids with tert ‐amines through C–N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction.