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Access to Pyrrole Derivatives in Water with the Assistance of Methylated Cyclodextrins
Author(s) -
Menuel Stéphane,
Rousseau Jolanta,
Rousseau Cyril,
Vaičiūnaite Edita,
Dodonova Jelena,
Tumkevičius Sigitas,
Monflier Eric
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402327
Subject(s) - catalysis , chemistry , condensation , pyrrole , aqueous solution , aqueous medium , organic chemistry , combinatorial chemistry , cyclodextrin , physics , thermodynamics
A new and efficient catalytic protocol with which to synthesize N ‐substituted pyrrole derivatives from amines and 1,4‐diketones by Paal–Knorr condensation in aqueous medium has been developed by using partially methylated β‐cyclodextrins (RAME‐β‐CD). The modified cyclodextrins were used as mass transfer agents without catalyst for reactive ketones and with nitrophenol as catalyst for more hindered ketones.