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One‐Pot Transformation of Methylarenes into Aromatic Nitriles with Inorganic Metal‐Free Reagents
Author(s) -
Kawagoe Yuhsuke,
Moriyama Katsuhiko,
Togo Hideo
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402270
Subject(s) - chemistry , reagent , ammonia , transition metal , organic chemistry , iodine , metal , combinatorial chemistry , catalysis
Various methylarenes were transformed into the corresponding aromatic nitriles in good to moderate yields by the treatment with aq. HBr and aq. H 2 O 2 , followed by reaction with molecular iodine and aq. ammonia in a one‐pot procedure. The present reaction is a useful, practical, transition‐metal‐free, and organic‐reagent‐free method for the preparation of aromatic nitriles from methylarenes.