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Copper(II)‐Mediated Homocoupling of Thioamides for the Synthesis of 1,2,4‐Thiadiazoles
Author(s) -
Sun Yadong,
Wu Wanqing,
Jiang Huanfeng
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402194
Subject(s) - thiadiazoles , chemistry , copper , combinatorial chemistry , transformation (genetics) , medicinal chemistry , organic chemistry , biochemistry , gene
A copper(II)‐mediated highly selective oxidative cyclization reaction of thioamides to provide 3,5‐disubstituted 1,2,4‐thiadiazoles was developed. The copper species plays a key role in this transformation and different functional groups are tolerated under the optimal reaction conditions.