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Efficient Domino Synthesis of Pyrrole‐Fused Isocoumarins with Microwave Heating
Author(s) -
Sun MuYan,
Meng XiaoYan,
Zhao FuJie,
Dang YiJing,
Jiang Fei,
Liu Kai,
Wang CongShuai,
Jiang Bo,
Tu ShuJiang
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402164
Subject(s) - chemistry , domino , regioselectivity , isocoumarins , ring (chemistry) , pyrrole , atom economy , cascade reaction , combinatorial chemistry , microwave heating , bond cleavage , transition metal , chemical synthesis , organic chemistry , microwave , nanotechnology , catalysis , biochemistry , materials science , in vitro , physics , quantum mechanics
A new three‐component approach to polyfunctionalized isochromeno[4,3‐ b ]pyrroles has been developed with excellent regioselectivity. During these domino reactions, two ring‐opening and three cyclization reactions were readily achieved through carbon–carbon bond cleavage under transition‐metal‐free conditions. The advantages of atom and step economy, and scope make this reaction a powerful tool for assembling tri‐heterocyclic scaffolds of general chemical and biomedical interest.