Premium
Suzuki–Miyaura Coupling of Aryl Sulfonates with Arylboronic Acids Using a Morpholine–Pd(OAc) 2 Catalyst System
Author(s) -
Abe Taichi,
Mino Takashi,
Watanabe Kohei,
Yagishita Fumitoshi,
Sakamoto Masami
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201402120
Subject(s) - morpholine , chemistry , aryl , catalysis , coupling (piping) , organic chemistry , combinatorial chemistry , medicinal chemistry , coupling reaction , mechanical engineering , alkyl , engineering
We report a new catalyst system, a morpholine–Pd(OAc) 2 complex, for Suzuki–Miyaura coupling of aryl tosylates or mesylates with arylboronic acids to give biaryl compounds. The morpholine–Pd(OAc) 2 catalyst system is proposed to be a precursor of the catalytically active species in the coupling reaction. Aryl chlorides and aryl triflates can also be used in this coupling reaction. Altogether, 22 biaryl compounds were obtained using this catalyst system.