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Copper(II)‐Catalyzed Aromatization Followed by Bromination of Cyclohexenones Leading to Phenols and Bromophenols
Author(s) -
Tong HungChun,
Reddy K. Rajender,
Liu ShiuhTzung
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201400158
Subject(s) - chemistry , halogenation , phenols , aromatization , catalysis , organic chemistry , copper , electrophile , phenol , enone , medicinal chemistry
Conversion of substituted cyclohexenones into the corresponding phenols can be achieved using copper acetate as the catalyst in the presence of LiBr and CF 3 COOH under oxygen. With the use of excess LiBr, electrophilic aromatic bromination afforded the corresponding bromophenol under similar catalytic conditions.