Mannich‐Type Addition Reactions between Lithium Derivatives of Benzo[ d ]thiazoles and  N ‐ tert ‐Butylsulfinyl‐3,3,3‐trifluoroacetaldimine: Convenient Generalized Synthesis of Bis(benzothiazole)s | Zendy

Mei Haibo | Zendy; Dai Yanling | Zendy; Wu Lingmin | Zendy; Soloshonok Vadim A. | Zendy; Han Jianlin | Zendy; Pan Yi | Zendy

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Mannich‐Type Addition Reactions between Lithium Derivatives of Benzo[ d ]thiazoles and N ‐ tert ‐Butylsulfinyl‐3,3,3‐trifluoroacetaldimine: Convenient Generalized Synthesis of Bis(benzothiazole)s

Author(s) -

Mei Haibo,

Dai Yanling,

Wu Lingmin,

Soloshonok Vadim A.,

Han Jianlin,

Pan Yi

Publication year - 2014

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201400118

Subject(s) - chemistry , benzothiazole , lithium (medication) , combinatorial chemistry , scope (computer science) , mannich reaction , medicinal chemistry , stereochemistry , organic chemistry , catalysis , medicine , endocrinology , computer science , programming language

This study describes the anomalous outcome of the Mannich‐type reaction of N ‐ tert ‐butylsulfinyl‐3,3,3‐trifluoroacetaldimine and Li derivatives of benzo[ d ]thiazoles, which offers a convenient and generalized method for the synthesis of biologically relevant ( E )‐1,2‐bis(2‐benzothiazolyl)ethanes. The mechanism, scope, and scalability of this new reaction are discussed.

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