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Synthesis of Oxindoles through Silver‐Catalyzed Trifluoromethylation–, Difluoromethylation– and Arylsulfonylation–Cyclization Reaction of N ‐Arylacrylamides
Author(s) -
Liu Jidan,
Zhuang Shaobo,
Gui Qingwen,
Chen Xiang,
Yang Zhiyong,
Tan Ze
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201400087
Subject(s) - trifluoromethylation , chemistry , reagent , aryl , sulfinic acid , catalysis , trifluoromethyl , organic chemistry , combinatorial chemistry , alkyl
Abstract Efficient synthesis of trifluoromethyl and difluoromethyl‐substituted oxindoles was achieved by reacting Langlois reagent or Baran reagent with N ‐arylacrylamides. However, the reaction of aryl sulfinic acid sodium salts with N ‐arylacrylamides did not give the desulfinative products, instead, aryl sulfonated products were produced.