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Access to 3‐Arylindoles through a Tandem One‐Pot Protocol Involving Dearomatization, a Regioselective Michael Addition Reaction, and Rearomatization
Author(s) -
Chittimalla Santhosh Kumar,
Bandi Chennakesavulu,
Putturu Sireesha,
Kuppusamy Rajesh,
Boellaard Kevin Christopher,
Tan David Chu Aan,
Lum Demi Ming Jie
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201400079
Subject(s) - regioselectivity , chemistry , tandem , michael reaction , combinatorial chemistry , organic chemistry , catalysis , materials science , composite material
A facile, general and rapid protocol for the introduction of oxygenated aryls at the 3‐position of indoles is described. This approach consists of a tandem dearomatization, a regioselective Michael addition reaction, and rearomatization in a one‐pot three‐step sequence to obtain 3‐arylindoles in good yields.