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Regioselective Hydrodebromination of Polybrominated Indoles
Author(s) -
Chelucci Giorgio,
Pinna Gérard A.,
Pinna Giansalvo
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201400032
Subject(s) - regioselectivity , chemistry , sodium borohydride , tetramethylethylenediamine , catalysis , polybrominated diphenyl ethers , organic chemistry , medicinal chemistry , palladium , pollutant
The mixture of sodium borohydride and N , N , N′ , N′ ‐tetramethylethylenediamine in combination with a palladium catalyst is a mild and efficient system for the regioselective hydrodebromination of polybrominated indoles with both N ‐donating and N ‐withdrawing substituents [ N ‐methyl‐ and N ‐(methoxycarbonyl)indoles, respectively].