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Sulfoxonium and Sulfonium Ylides as Diazocarbonyl Equivalents in Metal‐Catalyzed Insertion Reactions (Eur. J. Org. Chem. 23/2013)
Author(s) -
Burtoloso Antonio C. B.,
Dias Rafael M. P.,
Leonarczyk Ives A.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201390064
Subject(s) - sulfonium , chemistry , ylide , intramolecular force , insertion reaction , catalysis , sulfur , iridium , stereochemistry , medicinal chemistry , organic chemistry , salt (chemistry)
The cover picture shows freshly recrystallized sulfur plates. The scheme illustrates the synthesis of MK‐7246 by Merck, which involves an intramolecular N–H insertion reaction of a sulfur ylide as the key step (C. Molinaro, P. G. Bulger, E. E. Lee, B. Kosjek, S. Lau, D. Gauvreau, M. E. Howard, D. J. Wallace, P. D. O'Shea, J. Org. Chem. 2012 , 77 , 2299–2309). The reaction is mediated by iridium catalysis. Details are presented in the Microreview by A. C. B. Burtoloso et al. on page 5005 ff. The background image is used courtesy of Ryoji Tanaka (Sagami Chemical Research Institute).