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Gold–Ferrocene Glyco‐Nanoparticles for High‐Sensitivity Electrochemical Detection of Carbohydrate–Lectin Interactions (Eur. J. Org. Chem. 14/2013)
Author(s) -
MartosMaldonado Manuel C.,
Thygesen Mikkel B.,
Jensen Knud J.,
VargasBerenguel Antonio
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201390036
Subject(s) - chemistry , ferrocene , surface plasmon resonance , colloidal gold , concanavalin a , electrochemistry , nanoparticle , lectin , moiety , combinatorial chemistry , photochemistry , nanotechnology , electrode , stereochemistry , biochemistry , materials science , in vitro
The cover picture shows a gold nanoparticle coated with ferrocene–mannose conjugates bound to lectin concanavalin A. The binding triggers an optical and electrochemical signal that can be measured by both optical and electrochemical methods, based on the surface‐plasmon‐resonance (SPR)‐shifted properties of the metal and electrochemical activity of the ferrocene moiety, respectively. Such nanoparticles can detect concanavalin A with high sensitivity in the low nanomolar range by electrochemical methods. The background picture portrays a section of the coast of Cabo de Gata, which is close to the University of Almeria. Details are discussed in the article by K. J. Jensen, A. Vargas‐Berenguel et al. on p. 2793 ff .