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Off the Beaten Track: The Use of Secondary Amines in the Ugi Reactiong (Eur. J. Org. Chem. 10/2013)
Author(s) -
Tron Gian Cesare
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201390024
Subject(s) - chemistry , ugi reaction , amine gas treating , primary (astronomy) , swap (finance) , cover (algebra) , combinatorial chemistry , isocyanide , chemical space , track (disk drive) , organic chemistry , drug discovery , computer science , biochemistry , mechanical engineering , physics , finance , astronomy , engineering , economics , operating system
The cover picture shows how the deviation from the classical Mumm rearrangement, induced by a primary‐to‐secondary amine swap in the Ugi four‐component reaction, gives the possibility to chemists to discover novel synthetic strategies and to explore uncharted territories in the chemical space. The replacement of a primary amine with a secondary one is therefore like leaving the old road for a new one. Details are presented in the Microreview by G. C. Tron on p. 1849 ff. The author thanks A. Massarotti for his contribution in designing the cover picture.