Premium
Synthesis of Monoconjugated and Multiply Conjugated Oligonucleotides by “Click Thiol” Thiol‐Michael‐Type Additions and by Combination with CuAAC “Click Huisgen” (Eur. J. Org. Chem. 3/2013)
Author(s) -
Meyer Albert,
Vasseur JeanJacques,
Morvan François
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201390003
Subject(s) - oligonucleotide , click chemistry , cycloaddition , chemistry , conjugated system , biomolecule , alkyne , combinatorial chemistry , thiol , azide , dna , organic chemistry , polymer , catalysis , biochemistry
The cover picture shows that oligonucleotide conjugates with different biomolecules or markers could be obtained through the reaction between a thiol function of the oligonucleotide and an acrylamide function of the biomolecule or marker according to a Thiol‐Michael‐Type Addition (TMTA). This reaction could be combined sequentially with a Copper(I)‐catalyzed Azide–Alkyne Cycloaddition (CuAAC) affording bis‐conjugated oligonucleotides. These “click” reactions allow the preparation of a bouquet of molecules where their stem is a DNA sequence. This picture was inspirited by Picasso's “Bouquet with Hands”. The background is an autumn view of the countryside of Montpellier. Details are discussed in the article by F. Morvan et al. on p. 465 ff. The cover picture was elaborated by Thibault Morvan.