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Direct Trifluoromethylthiolation Reactions: The “Renaissance” of an Old Concept
Author(s) -
Toulgoat Fabien,
Alazet Sébastien,
Billard Thierry
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301857
Subject(s) - the renaissance , toolbox , chemistry , lipophilicity , work (physics) , management science , epistemology , computer science , organic chemistry , engineering , art history , philosophy , programming language , art , mechanical engineering
Because of its high lipophilicity, the CF 3 S group has always interested chemists. However, strategies to introduce it into organic molecules have been, for the most part, reserved to specialized “fluorine chemists”. Recent published work has demystified these preconceived ideas by proposing new efficient methods or easy‐to‐handle reagents to enrich the toolbox of chemists. However, all these new concepts arise from the pioneering works of the past! In this review, we will do a “back to the future” by remembering the most significant results of the past and by presenting extensions and novelties of the present and for the future.