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trans ‐Hexahydrobenzoxazolidinones in the Enantioselective Synthesis of β 2 ‐Amino Acids Containing Proteinogenic Side Chains
Author(s) -
Bandala Yamir,
ReyesRangel Gloria,
ObregónZúñiga Arturo,
CruzHernández Carlos,
Corzo Gerardo,
Juaristi Eusebio
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301834
Subject(s) - enantioselective synthesis , enantiopure drug , chemistry , enantiomer , side chain , stereochemistry , amino acid , absolute configuration , organic chemistry , catalysis , biochemistry , polymer
The use of enantiopure trans ‐hexahydrobenzoxazolidinones as chiral auxiliaries in the enantioselective synthesis of two β 2 ‐amino acids containing proteinogenic side chains (β 2 ‐hPhenylalanine and β 2 ‐hLysine), in both enantiomeric forms, is described. Absolute configurations were assigned on the basis of X‐ray diffraction analysis and chemical correlation methods.