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Sequential C3 and C5 Direct C–H Arylation of Imidazo[1,2‐ a ]pyrazines with (Hetero)aryl Bromides
Author(s) -
Johnson Brett M.,
Huestis Malcolm P.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301802
Subject(s) - chemistry , aryl , palladium , surface modification , combinatorial chemistry , catalysis , reaction conditions , organic chemistry , alkyl
An efficient reaction manifold for the preparation of C3/C5‐diarylimidazo[1,2‐ a ]pyrazines through sequential C3 and C5 direct arylation is disclosed. The two distinct palladium catalyst systems showcased herein are compatible with a wide variety of aryl and heteroaryl bromides and are also operative in a one‐pot, twofold C–H functionalization event.