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Hidden Flexibility of Strychnine
Author(s) -
Schmidt Manuel,
Reinscheid Frauke,
Sun Han,
Abromeit Hans,
Scriba Gerhard K. E.,
Sönnichsen Frank D.,
John Michael,
Reinscheid Uwe M.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301760
Subject(s) - strychnine , chemistry , rigidity (electromagnetism) , flexibility (engineering) , computational chemistry , molecule , structural rigidity , organic chemistry , physics , quantum mechanics , biochemistry , statistics , mathematics , geometry
The prototypic molecule for conformational rigidity, that is, strychnine, exhibits fast conformational exchange on the NMR timescale at room temperature. A comprehensive description of this up‐to‐now‐hidden stereodynamic behavior is presented, which combines experimental and computational data.