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Metal‐Free Oxidative Cyclization of o ‐Acylphenols for the Construction of 2‐Aminobenzofuran‐3(2 H )‐ones
Author(s) -
Yu Hui,
Huang Weihua,
Zhang Fengling
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301756
Subject(s) - chemistry , catalysis , oxidative phosphorylation , metal , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry
An efficient metal‐free approach to the synthesis of 2‐aminobenzofuran‐3(2 H )‐ones has been developed. Using TBHP as an oxidant and I 2 (or TBAI) as catalyst, 2‐acylphenols were treated with secondary amines to provide 2‐aminobenzofuran‐3(2 H )‐one derivatives in moderate to good yields. A possible reaction pathway for the formation of 2‐dimorpholinobenzofuran‐3(2 H )‐one is also discussed herein.