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Nucleoside Analogues: Synthesis and Biological Properties of Azanucleoside Derivatives
Author(s) -
Hernández Dácil,
Boto Alicia
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301731
Subject(s) - chemistry , nucleoside , furanose , combinatorial chemistry , oligonucleotide , ring (chemistry) , stereochemistry , nucleoside analogue , nucleic acid , antimicrobial , dna , biochemistry , organic chemistry
Abstract The azanucleosides are nucleoside analogues where the furanose ring is replaced by a nitrogen‐containing ring or chain. Many azanucleosides are potent antiviral, anticancer and antimicrobial agents, or serve as valuable components of oligonucleotides with improved stability, binding or hybridization properties. Therefore, the development of new analogues is a very active area in medicinal and synthetic chemistry. Their synthesis and their interesting biological properties are discussed in this microreview.