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The Alternative Route to Enantiopure Multicomponent Reaction Products: Biocatalytic or Organocatalytic Enantioselective Production of Inputs for Multicomponent Reactions
Author(s) -
Banfi Luca,
Basso Andrea,
Moni Lisa,
Riva Renata
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301715
Subject(s) - enantiopure drug , enantioselective synthesis , chemistry , organocatalysis , substrate (aquarium) , catalysis , organic chemistry , combinatorial chemistry , biocatalysis , biochemical engineering , reaction mechanism , geology , engineering , oceanography
To access enantiopure multicomponent reaction (MCR) products, the two most convenient approaches are (1) the development of an asymmetric catalytic version of the MCR, starting from achiral substrates; and (2) the use of chiral, enantiomerically pure inputs by taking advantage of the substrate‐controlled diastereoselection achieved during the MCR step. In this microreview we will focus on the second alternative strategy and, more specifically, on the generation of chiral inputs through biocatalytic or organocatalytic methodologies.