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1,2,3‐Triazole in Heterocyclic Compounds, Endowed with Biological Activity, through 1,3‐Dipolar Cycloadditions
Author(s) -
Lauria Antonino,
Delisi Riccardo,
Mingoia Francesco,
Terenzi Alessio,
Martorana Annamaria,
Barone Giampaolo,
Almerico Anna Maria
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301695
Subject(s) - cycloaddition , chemistry , triazole , combinatorial chemistry , ring (chemistry) , click chemistry , 1,3 dipolar cycloaddition , molecule , linker , domino , ruthenium , stereochemistry , computational chemistry , organic chemistry , catalysis , computer science , operating system
1,3‐Dipolar cycloaddition reactions can be considered a powerful synthetic tool in the building of heterocyclic rings, with applications in different fields. In this review we focus on the synthesis of biologically active compounds possessing the 1,2,3‐triazole core through 1,3‐dipolar cycloaddition reactions. The 1,2,3‐triazole skeleton can be present as a single disubstituted ring, as a linker between two molecules, or embedded in a polyheterocycle. The cycloaddition reactions are usually catalysed by copper or ruthenium. Domino reactions can be achieved through dipolarophile anion formation, generally followed by cyclisation. The variety of attainable heterocyclic structures gives an illustration of the importance of the 1,2,3‐triazole core in medicinal chemistry.