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Enantioselective Synthesis of Spirooxindole α‐ exo ‐Methylene‐γ‐butyrolactones from 3‐OBoc‐Oxindoles
Author(s) -
Jayakumar Samydurai,
Muthusamy Subramaniam,
Prakash Muthuraj,
Kesavan Venkitasamy
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301684
Subject(s) - chemistry , enantioselective synthesis , methylene , lewis acids and bases , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
Chiral Lewis bases facilitated the synthesis of highly functionalized spirooxindoles containing α‐ exo ‐methylene‐γ‐butyrolactones in high yields (76–92 %) and excellent enantioselectivities (up to 98 % ee ) at ambient temperature.
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