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Convenient Synthesis of Arylboronates through a Synergistic Pd/Cu‐Catalyzed Miyaura Borylation Reaction under Atmospheric Conditions
Author(s) -
Ratniyom Jadsada,
Dechnarong Nattanee,
Yotphan Sirilata,
Kiatisevi Supavadee
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301634
Subject(s) - borylation , chemistry , catalysis , aryl , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , reaction conditions , organic chemistry , biochemistry , alkyl , receptor
A highly efficient and practical borylation reaction of aryl iodides with bis(pinacolato)diboron has been established. By using Pd(OAc) 2 , CuI, and PPh 3 as a ligand at room temperature under air in the presence of Cs 2 CO 3 , the protocol proved to be general. Various functionalized arylboronates were obtained in moderate to excellent yields. In addition, a possible reaction mechanism was proposed.