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α‐Nitro Epoxides in Organic Synthesis: Development of a One‐Pot Organocatalytic Strategy for the Synthesis of Quinoxalines
Author(s) -
Ibrahim Mohammad M.,
Grau Dominik,
Hampel Frank,
Tsogoeva Svetlana B.
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301591
Subject(s) - chemistry , nitro , organic chemistry , condensation , combinatorial chemistry , catalysis , organocatalysis , enantioselective synthesis , alkyl , physics , thermodynamics
A new strategy for the synthesis of biologically active quinoxalines by using versatile α‐nitro epoxides as starting compounds has been developed. In addition, the in situ organocatalytic epoxidation of electron‐poor nitro olefins followed by condensation with 1,2‐phenylenediamines to provide quinoxalines in one pot has been demonstrated.