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The Acrylamide Moiety as an Activated Alkene Component in the Intramolecular Baylis–Hillman Reaction: Facile Synthesis of Functionalized α‐Methylene Lactam and Spirolactam Frameworks
Author(s) -
Basavaiah Deevi,
Reddy Guddeti Chandrashekar,
Bharadwaj Kishor Chandra
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301526
Subject(s) - moiety , chemistry , alkene , methylene , intramolecular force , baylis–hillman reaction , combinatorial chemistry , acrylamide , organic chemistry , adduct , catalysis , polymer , copolymer
A facile strategy for the intramolecular Baylis–Hillman reaction by utilizing an acrylamide moiety as an activated alkene component was developed, which thus provides a convenient protocol for obtaining five‐ and six‐membered α‐methylene lactam and spirolactam derivatives.