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A Metal‐Free Route to CF 3 ‐Containing Oxindoles by PhI(OAc) 2 ‐Mediated Trifluoromethylation of N ‐Arylacrylamides with TMSCF 3
Author(s) -
Fu Weijun,
Xu Fengjuan,
Fu Yuqin,
Xu Chen,
Li Shihui,
Zou Dapeng
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301512
Subject(s) - trifluoromethylation , chemistry , metal , reaction conditions , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , catalysis , alkyl , trifluoromethyl
Abstract A mild and efficient PhI(OAc) 2 ‐mediated trifluoromethylation reaction of N ‐arylacrylamides with TMSCF 3 under metal‐free conditions was developed. This method provides convenient access to a variety of useful CF 3 ‐containing oxindoles in moderate to good yields.