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Premium Enantioselective Synthesis of Spirooxindoles: Asymmetric [3+2] Cycloaddition of (3‐Isothiocyanato)oxindoles with Azodicarboxylates
Jiang Yu,
Pei ChengKui,
Du Dan,
Li XiaoGe,
He YaNan,
Xu Qin,
Shi Min
Publication year2013
Publication title
european journal of organic chemistry
Resource typeJournals
PublisherWILEY‐VCH Verlag
Abstract The catalytic asymmetric [3+2] cycloaddition of (3‐isothiocyanato)oxindoles with azodicarboxylates has been explored in the presence of (DHQD) 2 PHAL. It affords spirooxindoles having two heterocycles at their C3′‐position in excellent yields, with high enantioselectivities, and under mild conditions within 5 min. Moreover, another spirooxindole derived from the reaction of (3‐isothiocyanato)oxindole with two molecules of azodicarboxylate could also be formed in excellent yields with the same high enantioselectivities under the standard conditions.
Subject(s)catalysis , chemistry , combinatorial chemistry , cycloaddition , enantioselective synthesis , organic chemistry , oxindole , stereochemistry
SCImago Journal Rank0.825

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