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Facile Assembly of 1‐[(Trifluoromethyl)thio]isoquinolines through Reaction of 2‐Alkynylbenzaldoxime with Silver (Trifluoromethyl)thiolate
Author(s) -
Xiao Qing,
Sheng Jie,
Ding Qiuping,
Wu Jie
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301401
Subject(s) - trifluoromethyl , chemistry , thio , moiety , isoquinoline , chloride , catalysis , medicinal chemistry , organic chemistry , alkyl
1‐[(Trifluoromethyl)thio]isoquinolines can be assembled through silver(I)‐catalyzed reaction of 2‐alkynylbenzaldoxime with silver (trifluoromethyl)thiolate in the presence of p ‐methoxybenzenesulfonyl chloride. The (trifluoromethyl)thio moiety (SCF 3 ) could be easily introduced into the scaffold of isoquinoline under mild conditions.