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Iron‐Catalyzed Three‐Component Synthesis of α‐Amino Acid Derivatives
Author(s) -
Halli Juliette,
Manolikakes Georg
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301349
Subject(s) - chemistry , catalysis , component (thermodynamics) , amide , combinatorial chemistry , atom economy , organic chemistry , physics , thermodynamics
An efficient, iron‐catalyzed, three‐component synthesis of arylglycines starting from readily available amides, glyoxalates, and arenes or heteroarenes has been developed. This method provides a versatile, atom‐economic, and cost‐effective route to arylglycines with water as the only byproduct. With carbamates as the amide component, various synthetically useful N ‐protected arylglycine derivatives could be prepared.